Open AccessLong‐term Prognosis for Non‐ischemic Heart Disease Patients with Premature Ventricular Contraction and Non‐sustained Ventricular Tachycardia
Author(s) -
Komoriya Masakazu,
Imai Shinobu,
Aoyama Hiroshi,
Yagi Hideki,
Nagashima Masaaki,
Enomoto Mitsunobu,
Suzuki Kazutaka,
Yamaji Satoshi,
Takase Hidehito,
Matsudaira Kagari,
Takahashi Naoyuki,
Saito Fumio,
Yagi Hiroshi,
Kushiro Toshio,
Nagao Ken,
Hirayama Atsushi
Publication year - 2008
Publication title -
journal of arrhythmia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.463
H-Index - 21
eISSN - 1883-2148
pISSN - 1880-4276
DOI - 10.1016/s1880-4276(08)80003-8
Subject(s) - medicine , cardiology , ventricular tachycardia , heart failure , hypertensive heart disease , ace inhibitor , heart disease , angiotensin converting enzyme , blood pressure
There are few long‐term reports of patients with frequent PVCs in the absence of ischemic heart disease. In 86 patients without ischemic heart disease, who had 1000 or more PVCs in 24‐hour Holter ECG, the number of PVCs during 24‐hours Holter ECG and echocardiographic parameters were followed at least 1 year (66.5 ± 39.7 months). PVC was significantly reduced in the patients with or without underlying diseases (UD). The reduction rate in the number of PVCs was prominent in patients with UD. PVC was significantly reduced in patients under medication, but not in patients without medication. In the comparison between the initial and follow up observation using Wilcoxon's rank test, the number of PVC was significantly reduced (P < 0.05), and EF was also improved (P < 0.05) in angiotensin converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) group, and in β‐blocker group. In Ca‐antagonist group and antiarrhythmic drug group, the number of PVCs was also significantly reduced (P < 0.05). Multivariate analysis revealed significantly higher incidence (60% or more with PVC reduction) in ACEI/ARB group. These results suggest that the administration of ACEI/ARB may contribute to the reduction of PVC in non‐ischemic heart disease cases with multiple PVC.