Open AccessRepair of the Canine Vertebral Lamina With a Combination of Autologous Micromorselized Bone and Poly‐Lactic Acid Gel After a Total Laminectomy
Author(s) -
Chuang JinPeng,
Chang ChihPeng,
Shen HungTau,
Kao Jiun,
Yan JingLung
Publication year - 2010
Publication title -
the kaohsiung journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.439
H-Index - 36
eISSN - 2410-8650
pISSN - 1607-551X
DOI - 10.1016/s1607-551x(10)70059-0
Subject(s) - medicine , laminectomy , lamina , surgery , adhesion , spinal canal stenosis , stenosis , spinal stenosis , lumbar , spinal cord , spinal canal , anatomy , radiology , chemistry , psychiatry , organic chemistry
The complications of a total laminectomy can include epidural scar adhesion, secondary vertebral canal stenosis and lumbar instability. The aim of this study was to assess the ability of a combination of autologous micromorselized bone and polylactic acid (PLA) gel to stimulate bone repair within canine vertebral lamina defects, as well as to prevent peridural adhesion following a laminectomy. Twenty dogs underwent a L1, L3 and L5 laminectomy after a pre‐computed tomography examination. The 60 laminectomies were divided into 4 groups, and underwent the following treatments: Group A were treated with a combination of autologous micromorselized bone and PLA gel ( n = 16); Group B were treated with micromorselized bone only ( n = 16); Group C with PLA gel only ( n = 14); and Group D were left untreated as they were the blank controls ( n = 14). Vertebral laminae were harvested at 4 th and 8 th weeks, and examined by computed tomography and histological staining. Significant bone regeneration was observed at 4 and 8 weeks in Groups A and B, although the newly formed bone in the latter group was more irregular in shape. Spinal canal cross‐sectional areas in Group B decreased as compared with those in Group A( p < 0.05), and the degree of peridural adhesion in Groups A and C was significantly lower compared with Groups B and D ( p < 0.05). These findings indicate that a combination of micromorselized bone and PLA gel may provide a better strategy for the treatment of spinal stenosis.