Open AccessMalignant Transformation of a Benign Oncocytoma of the Submandibular Gland: A Case Report
Author(s) -
Lee TsungHsun,
Lin YungSong,
Lee WenYing,
Wu TaiChing,
Chang ShihLun
Publication year - 2010
Publication title -
the kaohsiung journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.439
H-Index - 36
eISSN - 2410-8650
pISSN - 1607-551X
DOI - 10.1016/s1607-551x(10)70047-4
Subject(s) - oncocytoma , medicine , submandibular gland , pathology , atypia , malignant transformation , benign tumor , carcinoma , immunohistochemistry
Oncocytic carcinoma arising in the submandibular gland is an extremely rare tumor and only 11 cases have been reported previously. We report on a 51‐year‐old man with a previously benign oncocytoma in the submandibular gland that transformed from a benign morphology to malignant cellular atypia and mitosis. To our knowledge, the current report is the first published case of a malignant transformation from benign oncocytoma to oncocytic carcinoma of the submandibular gland. The proliferative activity of the tumor cells was evaluated immunohistochemically using antibodies against Ki‐67.