Open AccessExpression of Thyroid Hormone Receptors in Intracranial Meningiomas
Author(s) -
Wang ChihJen,
Lin PiChu,
Howng ShenLong
Publication year - 2003
Publication title -
the kaohsiung journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.439
H-Index - 36
eISSN - 2410-8650
pISSN - 1607-551X
DOI - 10.1016/s1607-551x(09)70434-6
Subject(s) - medicine , thyroid , hormone , meningioma , receptor , thyroid hormone receptor , hormone receptor , reverse transcription polymerase chain reaction , pathology , cancer research , gene , gene expression , cancer , biology , genetics , breast cancer
Thyroid hormone has a unique function in human organs. Many of its effects occur at the level of gene expression and are mediated by thyroid hormone receptors (TRs). We investigated the relationship between TRs and the prognosis of meningiomas. We investigated TR expression in human intracranial meningiomas using reverse transcription‐polymerase chain reaction. Specimens of 25 tumors were obtained by craniotomy from various intracranial meningiomas. We found that the expression of TRs was receptor subtype‐ and cell type‐dependent. Human TRα1 (hTRα1) was expressed in nine cases, hTRα2 was expressed in 14 cases, and both hTR‐alpha‐1 and hTR‐alpha‐2 were expressed in five cases; hTRβ1 was expressed in nine cases of recurrent or malignant tumors. The expression of hTRβ1 may be an indicator of recurrent or malignant meningiomas.