Open AccessDengue Virus‐Associated Hemophagocytic Syndrome and Dyserythropoiesis: A Case Report
Author(s) -
Lu PoLiang,
Hsiao HuiHwa,
Tsai JihJin,
Chen TunChieh,
Chen TyenPo,
Lin ShengFung,
Feng MingChu
Publication year - 2005
Publication title -
the kaohsiung journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.439
H-Index - 36
eISSN - 2410-8650
pISSN - 1607-551X
DOI - 10.1016/s1607-551x(09)70274-8
Subject(s) - hemophagocytosis , dengue fever , medicine , dengue virus , serology , bone marrow , virology , immunology , antibody , pancytopenia
A 33‐year‐old man had dengue hemorrhagic fever with initial presentation of fever, leukocytosis, and thrombocytopenia. The cause of the subsequent rapid decline in red cell counts without evidence of intravascular hemolysis or massive bleeding was confirmed as hemophagocytosis and dyserythropoiesis by bone marrow study. The patient recovered with supportive care and the bone marrow pattern was normal on repeated bone marrow study. To our knowledge, this is the first reported case of dengue virus‐associated hemophagocytosis and dyserythropoiesis in Taiwan. Clinicians should consider that the occurrence of hemophagocytosis and dyserythropoiesis could be due to dengue virus infection. That this dengue virus infection was confirmed by a positive serology result at the convalescent stage but not at the acute symptomatic stage underlines the need for a second dengue serology study, as dengue infection can be missed due to an initial negative serology result.