Open AccessAdjunctive Treatment of Acute Mania with Risperidone versus Typical Antipsychotics: A Retrospective Study
Author(s) -
Tsai JuiHsiu,
Yen JuYu,
Tang TzeChun,
Yang Pinchen,
Yen ChengFang,
Yang MingJen,
Chen ChengChung
Publication year - 2005
Publication title -
the kaohsiung journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.439
H-Index - 36
eISSN - 2410-8650
pISSN - 1607-551X
DOI - 10.1016/s1607-551x(09)70205-0
Subject(s) - risperidone , medicine , mania , adjunctive treatment , psychiatry , mood , clinical global impression , adverse effect , retrospective cohort study , bipolar disorder , pediatrics , schizophrenia (object oriented programming) , placebo , alternative medicine , pathology
Few studies have directly compared atypical antipsychotics (e.g. risperidone) with typical antipsychotics as adjunctive therapy in patients hospitalized for acute mania, especially during a lengthy hospital stay. Our retrospective, case‐controlled study is a chart review of 64 patients with Diagnostic and Statistical Manual of Mental Disorders, 4 th edition, defined bipolar I disorder (current episode, mania). Patients were divided into two groups according to the adjunctive medications used: the risperidone group (mood stabilizers plus risperidone) and the control group (mood stabilizers plus typical antipsychotics). Outcome at discharge, medications, adverse drug effects, and length of hospital stay were compared between groups, controlling for gender, age, number of prior admissions, and duration of illness. Results indicated no statistically significant differences between groups in the controlled factors, Global Assessment of Functioning and Clinical Global Impression‐Improvement scores, and adverse drug events. Patients in the risperidone group used significantly lower doses of trihexyphenidyl than those in the control group ( p < 0.05). Patients treated with risperidone had a shorter hospital stay than those treated with typical antipsychotics ( p < 0.01). In conclusion, antipsychotics are effective as adjunctive agents in the treatment of acute mania. The use of risperidone, in particular, decreases the need for anticholinergics and may lead to a shorter hospital stay compared with typical antipsychotics.