Open AccessPure Red Cell Aplasia After ABO Major‐Mismatched Allogeneic Peripheral Blood Stem Cell Transplantation Successfully Treated with Plasma Exchange and Low‐Dose Steroid: Two Case Reports
Author(s) -
Tsai HuiJen,
Lin ShengFung,
Liu TaChih,
Chang ChaoSung,
Hsiao HuiHua,
Chen TyenPo
Publication year - 2004
Publication title -
the kaohsiung journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.439
H-Index - 36
eISSN - 2410-8650
pISSN - 1607-551X
DOI - 10.1016/s1607-551x(09)70096-8
Subject(s) - medicine , abo blood group system , pure red cell aplasia , transplantation , complication , stem cell , surgery , peripheral blood stem cells , titer , peripheral , aplasia , red blood cell , gastroenterology , immunology , hematopoietic stem cell transplantation , antibody , anemia , biology , genetics
Pure red cell aplasia (PRCA) is a complication of ABO‐incompatible allogeneic stem cell transplantation. The mechanism is not well known, although the isoagglutinin titer before transplantation or cyclosporine use is considered to be the cause. Patients with this complication require more blood transfusions than those without it. There is no standard treatment. We report two cases of PRCA after allogeneic peripheral blood stem cell transplantation that were successfully treated with plasma exchange and low‐dose steroid.