Open AccessClear Cell and Non‐Clear Cell Hepatocellular Carcinoma: A Case Report and Literature Review
Author(s) -
Liu JennHwa,
Tsai HueyLing,
Hsu SoaMing,
Hu DongHer,
Chen ShyShen
Publication year - 2004
Publication title -
the kaohsiung journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.439
H-Index - 36
eISSN - 2410-8650
pISSN - 1607-551X
DOI - 10.1016/s1607-551x(09)70088-9
Subject(s) - medicine , hepatocellular carcinoma , cell , pathology , mitosis , hepatectomy , liver cell , metastasis , cancer research , resection , cancer , biology , surgery , genetics , microbiology and biotechnology
Clear cell hepatocellular carcinoma (HCC) is an uncommon variant of HCC. It is considered to have a better prognosis than non‐clear cell HCC, but recent large studies show that there is some controversy. DNA image cytometry reveals diploid and non‐diploid DNA content tumors that have different pleomorphisms and mitosis corresponding to different prognoses. Clear cell HCC is classified as focal or diffuse. Herein, we report a rare case of a 61‐year‐old male with two adjacent hyper‐ and hypoechoic hepatic nodules and an !‐fetoprotein concentration of 6,370 ng/mL. Pathologic examination of a specimen obtained during wedge hepatectomy showed both clear cell and non‐clear cell HCC. Bone metastasis was later found. We suggest that a patient with clear cell HCC should be followed up closely after complete resection.