Open AccessOxcarbazepine‐induced Stevens‐Johnson Syndrome: A Case Report
Author(s) -
Lin LungChang,
Lai PingChin,
Yang SheauFang,
Yang ReiCheng
Publication year - 2009
Publication title -
the kaohsiung journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.439
H-Index - 36
eISSN - 2410-8650
pISSN - 1607-551X
DOI - 10.1016/s1607-551x(09)70045-2
Subject(s) - oxcarbazepine , medicine , carbamazepine , toxic epidermal necrolysis , human leukocyte antigen , genotyping , immunology , epilepsy , dermatology , antigen , genetics , genotype , psychiatry , gene , biology
Although carbamazepine (CBZ) is the most common cause of Stevens‐Johnson syndrome (SJS), a new anticonvulsant, oxcarbazepine, which is structurally related to carbamazepine, has been shown to induce SJS, although extremely rarely. Recently, a strong association was found between human leukocyte antigen (HLA) B*1502 and CBZ‐induced SJS/TEN in a Han Chinese population. Here, we report a case with SJS, which was induced by oxcarbazepine. HLA genotyping in the patient showed HLA‐B*1518/B*4001. HLA‐B*1518 is a HLA‐B15 variant. The genetic significance of HLA‐B*1518 in association with oxcarbazepine‐induced SJS needs to be further studied.