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Novel neuropeptides in the pathophysiology of heart failure: adrenomedullin and endothelin‐1
Author(s) -
Petrie Mark C.,
McClure Samuel J.,
Love Michael P.,
McMurray John J.V.
Publication year - 1999
Publication title -
european journal of heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.149
H-Index - 133
eISSN - 1879-0844
pISSN - 1388-9842
DOI - 10.1016/s1388-9842(98)00013-0
Subject(s) - adrenomedullin , medicine , heart failure , endothelin receptor , pathophysiology , hormone , endothelins , cardiology , intensive care medicine , bioinformatics , receptor , biology
The clinical success of neurohumoral manipulation by ACE inhibitors and beta blockers in heart failure has led to new therapeutic approaches. New neurohumoral factors are now viewed as offering the potential for treatment interventions. Not only do we consider blocking the production of deleterious hormones, but also, more recently, consideration has been given to augmenting the actions of factors with potentially beneficial actions. Hopefully such manipulation of ADM and ET-1 can result in further improvement in the well-being of heart failure patients.