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Relation of atrial natriuretic peptides to left ventricular systolic and diastolic function in heart failure
Author(s) -
Wijbenga Anke A.M.,
Balk Aggie H.M.M.,
Jonkman Fokke A.M.,
Boomsma Frans,
Simoons Maarten L.,
Man in 't Veld Arie J.
Publication year - 1999
Publication title -
european journal of heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.149
H-Index - 133
eISSN - 1879-0844
pISSN - 1388-9842
DOI - 10.1016/s1388-9842(98)00005-1
Subject(s) - medicine , cardiology , heart failure , ejection fraction , atrial natriuretic peptide , diastole , natriuretic peptide , blood pressure
Background: Plasma concentrations of atrial natriuretic peptides are correlated with atrial pressures, as are left ventricular ejection fraction and left ventricular filling abnormalities. Aims: This study investigated the relation of atrial natriuretic peptides to both left ventricular systolic and diastolic function in heart failure. Methods: Plasma concentrations of atrial natriuretic peptide and N‐terminal pro‐atrial natriuretic peptide were measured in 63 patients with chronic heart failure and left ventricular systolic dysfunction. According to Doppler transmitral flow measurements, 19 patients had a restrictive and 44 patients had a non‐restrictive left ventricular filling pattern. Results: Plasma concentrations of atrial natriuretic peptide and N‐terminal pro‐atrial natriuretic peptide were higher in patients with a restrictive filling pattern than in patients with a non‐restrictive filling pattern (197 vs. 75 pmol/l, P < 0.0001 and 1.14 vs. 0.45 nmol/l, P < 0.0001). In univariate analysis, atrial natriuretic peptide and N‐terminal pro‐atrial natriuretic peptide correlated with deceleration time, E/A ratio and left ventricular ejection fraction. In multivariate analysis, both peptides appeared independently related to left ventricular ejection fraction and left ventricular filling pattern. Conclusion: In patients with chronic heart failure, atrial natriuretic peptides provide information on left ventricular systolic as well as diastolic function.