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Determinants of platelet responsiveness to nitric oxide in patients with chronic heart failure
Author(s) -
Anderson R.A.,
Ellis G.R.,
Chirkov Y.Y.,
Holmes A.S.,
Payne N.,
Blackman D.J.,
Jackson S.K.,
Lewis M.J.,
Horowitz J.D.,
Frenneaux M.P.
Publication year - 2004
Publication title -
european journal of heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.149
H-Index - 133
eISSN - 1879-0844
pISSN - 1388-9842
DOI - 10.1016/s1388-9842(03)00038-2
Subject(s) - medicine , sodium nitroprusside , heart failure , oxidative stress , nitric oxide , cardiology , platelet , angina , cardiomyopathy , oxidative phosphorylation , myocardial infarction , biochemistry , chemistry
Congestive heart failure (CHF) is associated with oxidative stress. Platelet responsiveness to nitric oxide (NO) donors, are impaired in patients with angina pectoris, possibly by increasing oxidative stress. We investigated the occurrence of platelet resistance to NO in patients, with ischaemic or non‐ischaemic cardiomyopathy compared with normal subjects. Anti‐aggregatory effects of sodium nitroprusside (SNP), oxidative stress and whole blood superoxide anion content were determined, with correlates of responsiveness to SNP. Inhibition of platelet aggregation by SNP was 65.4±3.55% in controls and 59.3±4.1% in CHF ( P =ns) despite increased oxidative stress and post‐aggregation O 2 − in CHF patients. However, subsets of CHF patients have NO‐resistant platelets: this is associated with increasing age and/or increased oxidative stress (both p <0.05).