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Influence of progressive renal dysfunction in chronic heart failure
Author(s) -
Maxwell A. Peter,
Ong Hean Y.,
Nicholls D. Paul
Publication year - 2002
Publication title -
european journal of heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.149
H-Index - 133
eISSN - 1879-0844
pISSN - 1388-9842
DOI - 10.1016/s1388-9842(01)00238-0
Subject(s) - medicine , heart failure , cardiology , spironolactone , left ventricular hypertrophy , chronic renal failure , renal function , perfusion , pressure overload , cardiorenal syndrome , muscle hypertrophy , compensatory hypertrophy , blood pressure , acute tubular necrosis , cardiac hypertrophy
Chronic heart failure (CHF) is often associated with impaired renal function due to hypoperfusion. Such patients are very sensitive to changes in renal perfusion pressure, and may develop acute tubular necrosis if the pressure falls too far. The situation is complicated by the use of diuretics, ACE inhibitors and spironolactone, all of which may affect renal function and potassium balance. Chronic renal failure (CRF) may also be associated with fluid overload. Anaemia and hypertension in CRF contribute to the development of left ventricular hypertrophy (LVH), which carries a poor prognosis, so correction of these factors is important.