Premium
Relationship between cardiac metaiodobenzylguanidine uptake and hemodynamic, functional and neurohormonal parameters in patients with heart failure
Author(s) -
Milliano Paul A.R.,
EckSmit Berthe L.F.,
Zwieten Pieter A.,
Groot Andre C.,
Tijssen Jan G.P.,
Lie Kong I.
Publication year - 2001
Publication title -
european journal of heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.149
H-Index - 133
eISSN - 1879-0844
pISSN - 1388-9842
DOI - 10.1016/s1388-9842(01)00184-2
Subject(s) - heart failure , medicine , cardiology , hemodynamics , ejection fraction , norepinephrine , heart disease , dopamine
Background: Sympathetic activation plays a pivotal role in heart failure attributing to the disease process and symptoms of the patient. Myocardial sympathetic activity can be visualized using radioiodinated metaiodobenzylguanidine 123 I‐MIBG, a structural analogue of norepinephrine (NE). Aim of the study: We investigated whether a relation exists between myocardial MIBG uptake and different functional, hemodynamic and neurohormonal parameters in patients with chronic heart failure. Methods and results: The study comprised 52 patients with stable congestive heart failure functional class II or III and left ventricular ejection fractions of <35%. The heart/mediastinum ratio (H/M ratio) was calculated to quantify myocardial MIBG uptake. A significant correlation was found between peak oxygen consumption and maximal exercise duration as exercise parameters and H/M ratio of MIBG ( R , respectively, 0.36 and 0.4, P <0.05). From all other measured parameters, only plasma NE showed a significant correlation with the H/M ratio of MIBG. Conclusion: Cardiac sympathetic activity, as measured by myocardial MIBG uptake, is correlated with peak exercise parameters.