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Torsades de pointes caused by Mibefradil
Author(s) -
Gläser Sven,
Steinbach Michaela,
Opitz Christian,
Wruck Ullrich,
Kleber Franz X.
Publication year - 2001
Publication title -
european journal of heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.149
H-Index - 133
eISSN - 1879-0844
pISSN - 1388-9842
DOI - 10.1016/s1388-9842(01)00159-3
Subject(s) - mibefradil , torsades de pointes , medicine , qt interval , discontinuation , cardiology , prolongation , antagonist , receptor
We report a case of symptomatic Torsades de pointes due to QTc prolongation by Mibefradil, which potentially explains unexpected deaths related to this drug. Multiple episodes of Torsades de pointes were documented in a 76‐year‐old woman with significant QTc prolongation of 0.53 s. After discontinuation of Mibefradil QTc intervals normalized and no further ventricular tachyarrythmias were observed. We conclude that Mibefradil can cause QTc prolongation and life threatening ventricular dysrhythmias.