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Abnormal contractile responses during dobutamine stress echocardiography in patients with idiopathic dilated cardiomyopathy
Author(s) -
Richard M. de Jong,
Jan H. Cornel,
Harry J.G.M. Crijns,
Veldhuisen Dirk J.
Publication year - 2001
Publication title -
european journal of heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.149
H-Index - 133
eISSN - 1879-0844
pISSN - 1388-9842
DOI - 10.1016/s1388-9842(01)00143-x
Subject(s) - medicine , dobutamine , cardiology , dilated cardiomyopathy , cardiomyopathy , ejection fraction , heart failure , hemodynamics
Background: In chronic heart failure augmented wall stress leads to increased energy demand. Supply, however, may be reduced due to coronary vasoconstriction and endothelial dysfunction. This might lead to a mismatch between demand and supply. In the present study we further explored the effect of increased demand during dobutamine stress echocardiography. Methods and results: Sixteen patients with idiopathic dilated cardiomyopathy (mean age 44±13 years, New York Heart Association class II–III, mean left ventricular ejection fraction 0.27±0.10) underwent dobutamine stress echocardiography (5–40 μg/min per kg bodyweight+atropine if required). Wall motion and thickening was assessed in 16 segments using a four‐point scale. Eleven patients (69%) showed regions with worsening of wall motion or a biphasic response during dobutamine infusion. Of the remaining five patients one patient did not show any wall motion changes and one patient showed a partial improvement while only in three patients wall motion improvement in the whole heart was found. Conclusion: A majority of patients with idiopathic dilated cardiomyopathy showed decreased wall motion during increased demand, i.e. ischemia‐like myocardial contractile responses during dobutamine stress echocardiography. These findings further support the concept that an energy mismatch between demand and supply might play a pathophysiological role in idiopathic dilated cardiomyopathy.