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Risk factors in securing successful surgical resection of oral squamous cell carcinoma
Author(s) -
Nakanishi Yoshitaka,
Yamada Shinichi,
Nishizawa Rishiho,
Shimane Tetsu,
Kamata Takahiro,
Koike Takeshi,
Uehara Shinobu,
Kurita Hiroshi
Publication year - 2018
Publication title -
oral science international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.256
H-Index - 13
eISSN - 1881-4204
pISSN - 1348-8643
DOI - 10.1016/s1348-8643(18)30003-x
Subject(s) - medicine , basal cell , pathological , logistic regression , surgical margin , surgical resection , odds ratio , resection margin , surgery , univariate analysis , resection , retrospective cohort study , cancer , multivariate analysis , carcinoma
Abstract The purpose of this retrospective study was to analyze the factors that had a significant effect on securing a successful surgical resection (surgical margin) in oral cancer surgery. One hundred forty‐eight consecutive patients who underwent planned radical resection of oral squamous cell carcinoma (SCC) were analyzed. Successful resection was judged if pathological examination of the surgical specimen revealed a clear surgical margin (no SCC within 5 mm, n = 116), while an unsuccessful resection was judged if there was a close and involved surgical margin (SCC within 5 mm, n = 21; and SCC at margin, n = 11). Univariate analyses showed that gender, age, and T‐classification had significant influence on successful surgical resection. The results of multivariate logistic regression analysis showed that age (odds ratio [OR] = 1.042, 95% CI = 1.001‐1.084), T‐classification (OR = 1.656, 95% CI = 1.060‐2.587), and the presence of preoperative treatment (OR = 2.868, 95% CI = 1.047‐7.85) had significant effects on successful surgical resection. The results of this study suggested that successful resection of oral SCC was difficult in patients with either older age or advanced (T4) tumor. It is also suggested that preoperative therapy had a positive effect on securing a pathologically clear surgical margin.