Premium
Development and regeneration of salivary gland toward for clinical application
Author(s) -
Sakai Takayoshi
Publication year - 2015
Publication title -
oral science international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.256
H-Index - 13
eISSN - 1881-4204
pISSN - 1348-8643
DOI - 10.1016/s1348-8643(15)00040-3
Subject(s) - salivary gland , regeneration (biology) , salivary gland cancer , head and neck cancer , medicine , pathology , cancer , biology , microbiology and biotechnology
Salivary gland hypofunction, also termed as xerostomia, is caused by radiation therapy for head and neck cancer or Sjögren's syndrome, leading to a detrimental impact on oral health and quality of life. This review describes current studies on salivary gland development and the translational approaches of basic science to treating patients with dysfunction and hypofunction of the salivary gland. Here, we review the most recent studies that have offered better insight into the mechanisms of salivary gland development and regeneration. Furthermore, we highlight proposed approaches with the aim of recovering salivary gland function using both gene‐ and cell‐based therapy. A thorough understanding of the mechanisms involved in salivary gland development is necessary in order to design effective therapies for regeneration and repair of damaged salivary glands.