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Novel pathogenic role of fibrin as revealed by a case study on ligneous gingivitis
Author(s) -
Shimo Tsuyoshi,
Nishiyama Akiyoshi,
Kubota Satoshi,
Kurio Naito,
Okui Tatsuo,
Katase Naoki,
Hassan Nur Mohammad Monsur,
Honami Tatsuki,
Kishimoto Koji,
Mese Hiroshi,
Takigawa Masaharu,
Sasaki Akira
Publication year - 2011
Publication title -
oral science international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.256
H-Index - 13
eISSN - 1881-4204
pISSN - 1348-8643
DOI - 10.1016/s1348-8643(11)00025-5
Subject(s) - fibrin , gingivitis , wound healing , connective tissue , extracellular matrix , transforming growth factor , pathology , medicine , immunology , biology , microbiology and biotechnology , dentistry
Purpose of the research: Ligneous gingivitis is a rare disease characterized by nodular gingival enlargement secondary to fibrin deposits induced by micro‐injury in the gingiva, which disorder results from plasminogen (PLG) deficiency. Although none have investigated the association of wound healing factors with ligneous gingivitis. In this study, in addition to a histopathologic examination of ligneous gingivitis in a case of type I PLG deficiency, we further present data showing the effect of wound healing factors in association with fibrin in vitro to clarify the pathobiology of ligneous gingivitis in PLG‐deficient patients. Principle results: Immunohistochemical analysis revealed that transforming growth factor (TGF)‐β1, connective tissue growth factor/CCN2 (CCN2), and endothelin‐1 (ET‐1) had accumulated in the extracellular matrix around the epithelial and fibroblastic cells near the fibrin deposition. Consistent with these results, fibrin and TGF‐β1 synergistically up‐regulated CCN2 and ET‐1 gene expression in human dermal fibroblasts. Major conclusions: Fibrin plays a vicious role in ligneous gingivitis pathobiology by up‐regulating CCN2 and ET‐1 expression through the TGF‐β signaling pathway.