Premium
Morphometric Analysis of Nuclear Features and Volume‐Corrected Mitotic Index in the Prognosis of Oral Squamous Cell Carcinoma
Author(s) -
Natarajan Srikant,
Mahajan Sumita,
Boaz Karen,
George Thomas
Publication year - 2009
Publication title -
oral science international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.256
H-Index - 13
eISSN - 1881-4204
pISSN - 1348-8643
DOI - 10.1016/s1348-8643(09)80003-7
Subject(s) - mitotic index , basal cell , stepwise regression , oncology , medicine , carcinoma , mitosis , survival analysis , log rank test , pathology , nuclear medicine , biology , microbiology and biotechnology
In the present study, an objective and reproducible evaluation of mitotic activity and nuclear morphometric factors was attempted in 30 patients of oral squamous cell carcinoma with a view to predicting local relapse and survival. Various nuclear parameters and volume‐corrected mitotic index were calculated and compared with the recurrence and death of the study group (n = 30). Volume‐corrected mitotic index (M/V index) was the single best prognosticator for recurrence of oral squamous cell carcinoma (p = 0.008 for recurrence; p = 0.015 for death). The combination of M/V and SD of nuclear area (forward stepwise regression) was a more efficient and better predictor of survival (Log rank test, Kaplan‐Meier’s survival analysis; χ 2 = 17.46, p = 0.00001). The present study proved the effectiveness of the M/V index in predicting the biological behavior and the outcome of oral squamous cell carcinoma patients.