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Radiological Morphometric Analysis of the Mandibular Bone Structure after Ovariectomy in Mature Cynomolgus Monkeys
Author(s) -
Asai Hideomi,
Kozai Yusuke,
Matsumoto Yukiko,
Kawamata Ryota,
Kumasaka Satsuki,
Sakurai Takashi,
Kashima Isamu
Publication year - 2005
Publication title -
oral science international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.256
H-Index - 13
eISSN - 1881-4204
pISSN - 1348-8643
DOI - 10.1016/s1348-8643(05)80007-2
Subject(s) - radiography , osteoporosis , cortical bone , medicine , magnification , mandible (arthropod mouthpart) , bone mineral , perimeter , bone density , anatomy , dentistry , nuclear medicine , radiology , pathology , biology , geometry , mathematics , botany , computer science , computer vision , genus
【 Purpose】The effects of experimental osteoporosis on the trabecular bone structure of the mandible in cynomolgus monkeys were examined by radiological bone morphometric analysis. 【Methods】Ovariectomy OVXwas performed on twelve 10‐year‐old female cynomolgus monkeys, which were fed a controlled diet for 2 years. Twelve monkeys in a sham control group were fed under the same conditions. Using a microfocus tube and computed radiography, the removed mandibular bone samples were imaged by standardized magnification radiography, and two‐dimensional digital imaging data were obtained. The structural parameters, such as skeletal area, perimeter, number, complexity, continuity and anisotropy, were measured using radiological bone morphometric analysis. The bone mineral densityBMDwas measured by dual energy X‐ray absorptiometry. The width of the cortical bone was measured using magnified radiographic images. 【Results】There were no significant differences between the OVX and the sham control groups in the skeletal structure indicated by the skeletal volume, number, width, perimeter, complexity, continuity, separation and spacing. However, there were significant differences between the two groups in the BMD of the mandibular body, cortical bone width, anisotropy and some parameters of the skeletal continuity. Among these parameters, the difference in the thinning of the cortical bone was most significant. 【 Conclusions】Using two‐dimensional digital radiographic image data, this study suggests that the cortical bone width is more useful than the trabecular bone structure as the morphologic parameter for diagnosis of osteoporosis in the mandibular body