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Conditioned stress‐induced analgesia in humans
Author(s) -
Flor Herta,
Grösser Sabine M.
Publication year - 1999
Publication title -
european journal of pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.305
H-Index - 109
eISSN - 1532-2149
pISSN - 1090-3801
DOI - 10.1016/s1090-3801(99)90013-7
Subject(s) - heart rate , anesthesia , stimulus (psychology) , pain perception , medicine , classical conditioning , conditioning , blood pressure , psychology , mental arithmetic , audiology , statistics , mathematics , psychotherapist
The purpose of this experiment was the demonstration of conditioned stress‐induced analgesia in humans. Following a baseline day (day 1), two groups of 10 subjects were each exposed to green light as the conditioned stimulus (CS) and mental arithmetic plus noise as the unconditioned stimulus (US) for 5 days (days 2–6), a third group of 10 subjects was only exposed to the US. On the test day (day 7), pain threshold and pain tolerance were tested, while groups 1 and 3 received the green light CS and group 2 received no CS. Group 1 showed a significantly higher pain threshold and higher pain tolerance on the test day, whereas the two control groups did not have altered pain perception. Heart rate data confirmed successful stress induction. Heart rate and blood pressure were unaltered on the test day, thus making cardiovascular mediation of the conditioning effect unlikely. Conditioned stress analgesia might be useful in the understanding of chronic pain‐syndromes.