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Morphine‐3‐glucuronide prevents tolerance to morphine‐6‐glucuronide in mice
Author(s) -
Faura C.C.,
Olaso M.J.,
Horga J.F.
Publication year - 1997
Publication title -
european journal of pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.305
H-Index - 109
eISSN - 1532-2149
pISSN - 1090-3801
DOI - 10.1016/s1090-3801(97)90074-4
Subject(s) - morphine , glucuronide , pharmacology , chemistry , medicine , metabolism , biochemistry
Daily subcutaneous (s.c.) pretreatment with morphine‐3‐glucuronide (6 mg/kg) was found to reduce morphine‐6‐glucuronide (4 mg/kg s.c.)‐induced antinociception, with no decrease in the effect over 5 days. Morphine‐6‐glucuronide administration (4 mg/kg s.c.) on Day 6, without morphine‐3‐glucorinide pretreatment, results in a significant increase in antinociception (from 24% on Day 5 to 70%; p≤0.05). Morphine‐3‐glucuronide may prevent tolerance to morphine‐6‐glucuronide by reducing morphine‐6‐glucuronide‐induced antinociception.