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332 SYNERGISTIC ANALGESIC INTERACTION BETWEEN MORPHINE AND BIM‐46187
Author(s) -
Auguet M.,
FavreGuilmard C.,
ZeroualHider H.,
Prevost G.,
Chabrier P.E.
Publication year - 2006
Publication title -
european journal of pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.305
H-Index - 109
eISSN - 1532-2149
pISSN - 1090-3801
DOI - 10.1016/s1090-3801(06)60335-2
Subject(s) - sociology
male rats, but deteriorated withdrawal in females. Neither sex steroid hormones, nor phytoestrogens changed metamizol analgesic action. Mosaic immunohistochemical effects were revealed. Conclusion: Increasing pain sensitivity estradiol and phytoestrogens did not decrease metamizol and morphine analgesia. Data show that fluctuations in sex hormone levels should be considered for individualization of analgesic therapy.