Open AccessGranular Cell Tumor of the Thyroid
Author(s) -
Chang Su,
Chih-En Tseng,
ChangKuo Wei,
TzuCheng Su
Publication year - 2009
Publication title -
tzu-chi medical journal/cí-jì yīxué
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.343
H-Index - 15
eISSN - 2223-8956
pISSN - 1016-3190
DOI - 10.1016/s1016-3190(09)60012-4
Subject(s) - medicine , synaptophysin , thyroid , calcitonin , chromogranin a , vimentin , thyroglobulin , pathology , eosinophilic , cytokeratin , thyroid function , thyroid transcription factor 1 , immunohistochemistry , adenocarcinoma , cancer
Granular cell tumors (GCT) can occur in a wide variety of organs, but are rare in the thyroid. To the best of our knowledge, only four cases of thyroid GCT have been reported in the literature. We report a GCT of the thyroid in a girl aged 12 years who presented with a painless neck mass. Thyroid function tests and the serum calcium level were within normal limits. A thyroid ultrasound demonstrated a round hypoechoic mass in the thyroid isthmus. Histologically, the tumor cells demonstrated abundant granular eosinophilic cytoplasm. The tumor cells were positive for S-100 protein and vimentin, and were negative for thyroglobulin, calcitonin, thyroid transcription factor-1, chromogranin A, synaptophysin, and cytokeratin. The patient had no recurrence and remained well at the 10-month postoperative follow-up visit. We reviewed the literature for reports of thyroid GCTs and compared them with reports of extrathyroid GCTs