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Comparative postnatal development of dopamine D 1 , D 2 and D 4 receptors in rat forebrain
Author(s) -
Tarazi Frank I.,
Baldessarini Ross J.
Publication year - 2000
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/s0736-5748(99)00108-2
Subject(s) - nucleus accumbens , forebrain , dopamine , medicine , endocrinology , putamen , hippocampus , caudate nucleus , dopamine receptor , receptor , neuroscience , biology , central nervous system
Postnatal development of dopamine D 1 , D 2 and D 4 receptors in the caudate–putamen, nucleus accumbens, frontal cortex and hippocampus was assessed in rat brain between postnatal days 7 and 60. In the caudate–putamen and nucleus accumbens, density of all three receptor subtypes increased to a peak at postnatal day 28, then declined significantly in both regions (postnatal days 35–60) to adult levels. In the frontal cortex and hippocampus, these receptors rose steadily and continuously to stable, maximal adult levels by postnatal day 60. Evidently, D 1 , D 2 and D 4 receptors follow a similar course of development in several cortical, limbic and extrapyramidal regions of rat forebrain, with selective elimination of excess dopamine receptors at the time of puberty in the caudate–putamen and accumbens but not other brain regions.