Premium
Induction of tissue plasminogen activator in differentiated NG108‐15 cells
Author(s) -
Friedman Glenn C.,
Seeds Nicholas W.
Publication year - 2000
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/s0736-5748(99)00082-9
Subject(s) - neurite , plasminogen activator , tissue plasminogen activator , activator (genetics) , microbiology and biotechnology , cellular differentiation , biology , t plasminogen activator , messenger rna , chemistry , in vitro , endocrinology , biochemistry , gene
Plasminogen activators may facilitate neurite outgrowth and neuronal migration in the developing nervous system. The expression of tissue plasminogen activator by NG108‐15 neuroblastoma grown under a variety of conditions has been explored. High tissue plasminogen mRNA expression correlates with growth conditions which induce morphological differentiation and neurite outgrowth; however, NG108‐15 cells grown in suspension with dibutyryl‐cAMP also show a high level of tissue plasminogen activator expression.