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Effects of spermidine treatment on neurobehavioral development in intrauterine growth retarded (IUGR) rats
Author(s) -
Üzüm Gülay,
Diler A.Sarper,
Ziylan Ziya
Publication year - 1999
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/s0736-5748(99)00045-3
Subject(s) - righting reflex , spermidine , endocrinology , medicine , reflex , spmd , polyamine , physiology , biology , biochemistry , computer science , enzyme , operating system
It was previously shown that polyamine treatment could induce precocious development of several somatic and neurobehavioral functions in newborn rats. This study investigates the effects of daily injections of spermidine (SPMD) 50 μ l/10 g s.c. on neurobehavioral development of newborn rats experiencing undernutrition. Neurobehavioral development was assessed by measurements of gripping and righting reflexes. SPMD treated intrauterine growth retarded (IUGR) rats reached righting reflex control values at 30 days postnatal (1.87±0.78 s vs 1.75±0.66 s). Beginning from 7 days postnatal, gripping reflex values of SPMD treated IUGR rats declined, reaching that of controls at 30 days postnatal (1.77±91° vs 1.82±65°). These results suggest the utility of exogenous SPMD in rats experiencing undernutrition, thus indicating a clinical relevance.