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Plasticity of 5‐hydroxytryptamine 1B receptors during postnatal development in the rat visual cortex
Author(s) -
Ruiz Gloria,
Bancila Mircea,
Valenzuela Mauricio,
Daval Geneviève,
Hossein Kia Kami,
Vergé Daniel
Publication year - 1999
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/s0736-5748(99)00039-8
Subject(s) - enucleation , visual cortex , receptor , neuroscience , biology , serotonergic , cortex (anatomy) , endocrinology , medicine , serotonin , biochemistry , genetics
The distribution of 5‐hydroxytryptamine 1A and 5‐hydroxytryptamine 1B receptors in the visual cortex was studied by quantitative autoradiography during postnatal development. Overall, receptor densities increased throughout development, but exhibited regional rearrangements, particularly in the case of 5‐hydroxytryptamine 1B receptors. Neonatal treatment with 5,7‐dihydroxytryptamine, which causes selective degeneration of serotoninergic neurons, had no effect on the density of 5‐hydroxytryptamine 1A receptors in the visual cortex. However, a transient increase in 5‐hydroxytryptamine 1B at postnatal days 10–12 was observed after this treatment, suggesting a regulation of postsynaptic receptors. Neonatal enucleation resulted in a marked increase in 5‐hydroxytryptamine 1B binding sites in all layers of the visual cortex by P16, whereas it had no effect upon 5‐hydroxytryptamine 1A binding sites. These results show that both receptor subtypes do not exhibit striking transient features in the visual cortex during postnatal development, but rather undergo discrete reorganizations. 5‐Hydroxytryptamine 1B receptors show changes in density after either neonatal degeneration of serotoninergic neurons or enucleation, indicating that the serotoninergic system involving this receptor subtype can exhibit some postnatal plasticity in the visual cortex.