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Developmental and aging aspects of the cholinergicinnervation of the olfactory bulb
Author(s) -
Durand Marielle,
Coronas Valérie,
Jourdan François,
Quirion Rémi
Publication year - 1998
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/s0736-5748(98)00087-2
Subject(s) - olfactory bulb , basal forebrain , neuroscience , cholinergic , olfactory tubercle , olfactory system , cholinergic neuron , olfactory memory , biology , limbic system , central nervous system
The olfactory bulb is a limbic paleocortex which receives monosynaptic sensoryafferents from the olfactory mucosa, and a strong direct cholinergic input from the basal forebrain.This review focuses on the rat olfactory bulb as a suitable model to study cholinergicinvolvements in cortical processing, during development, adulthood and aging. Anatomical andbiochemical data show that cholinergic influences upon the bulbar neuronal network are exertedthrough several types of target cells and receptors (muscarinic and nicotinic). Functional dataindicate that cholinergic afferents to the olfactory bulb are involved in local events related toolfactory learning. Neurodegenerative disorders such as Alzheimers disease involve earlyolfactory deficits and typical histopathological lesions in the olfactory bulb. In summary, with itsexclusively extrinsic cholinergic innervation and direct sensory input, the rat olfactory bulb offersthe opportunity to study the cellular and molecular mechanisms of cholinergic influences oncortical processing, in both normal and pathological conditions.