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The neural mechanisms underlying cholinergic celldeath within the basal FOREBRAIN
Author(s) -
Wenk Gary L.,
Willard Lauren B.
Publication year - 1998
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/s0736-5748(98)00081-1
Subject(s) - nucleus basalis , basal forebrain , neuroscience , cholinergic , neocortex , cholinergic neuron , hippocampus , biology , forebrain , central nervous system
The basal forebrain region includes a large group of cholinergic neurons within themedial septal area and nucleus basalis magnocellularis (NBM) that project to the hippocampusand throughout the neocortex, respectively. This chapter will consider the mechanisms thatinfluence why cholinergic cells within the NBM die and discuss studies that have manipulated thefeatures of these cells that could make them differentially vulnerable to degeneration with agingand Alzheimer's Disease (AD). This chapter will focus upon the NBM cholinergic system because thisregions typically demonstrates a greater degree of cell loss with aging and AD.