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Role of NGF in axotomy‐induced c‐JUN expressionin medial septal cholinergic neurons
Author(s) -
Haas Carola A.,
Frotscher Michael
Publication year - 1998
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/s0736-5748(98)00079-3
Subject(s) - axotomy , neuroscience , nerve growth factor , cholinergic , cholinergic neuron , biology , degeneration (medical) , regeneration (biology) , anatomy , central nervous system , medicine , microbiology and biotechnology , pathology , receptor , biochemistry
The extent of neuronal regeneration after axotomy largely depends on the survivalcapacity of the injured cell. It has been shown for a long time that nerve fiber transection results inretrograde changes in the parent neuronal cell body, and that these changes may eventually lead toneuronal degeneration. 13 At present, little is known about the sequence of events initiatedin a nerve cell body by the transection of its axonal process. In this report, we will focus on aninteraction of nerve growth factor (NGF) with the transcription factor c‐Jun in intact andaxotomized septohippocampal projection neurons.