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Expression of the low affinity neurotrophin receptor, P75NGFR, in the rat forebrain, following unilateral bulbectomy
Author(s) -
Turner Christopher P.,
Perezpolo J.Regino
Publication year - 1998
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/s0736-5748(98)00016-1
Subject(s) - olfactory bulb , basal forebrain , olfactory system , neuroscience , olfactory nerve , forebrain , olfactory ensheathing glia , biology , olfactory receptor , neurotrophin , olfactory tubercle , cerebrum , central nervous system , endocrinology , medicine , receptor , biochemistry
It has been hypothesized that the main olfactory bulb, with its relatively rich source of neurotrophins, may provide trophic support for neurons that project to the bulb. We monitored expression of the common, low affinity receptor for neurotrophins, p75 NGFR , in the olfactory bulb and basal forebrain of unilaterally bulbectomized and sham‐treated rats, 1–16 weeks post‐surgery, using the monoclonal antibody MAb192. An induction of p75 NGFR ‐immunoreactivity was observed in both the glomerular and olfactory nerve layers of the right, contralateral main olfactory bulb of lesioned animals. The naturally occurring regeneration taking place in the olfactory neuroepithelium is known to be altered by olfactory bulbectomy, with subsequent changes in the sensory input to the remaining bulb. These changes in expression of p75 NGFR in the olfactory bulb support the hypothesis we have developed in previous papers, that changes in the extent of the peripheral input from the olfactory neuroepithelium to the main olfactory bulb regulate p75 NGFR expression in both the glomerular and the olfactory nerve layers. Expression of p75 NGFR in the basal forebrain of bulbectomized animals was found to be no different than sham‐treated controls and does not support the hypothesis that the olfactory bulb provides trophic support to this region of the central nervous system.