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Thyroid hormone action on astroglial cells fromdistinct brain regions during development
Author(s) -
Lima Flávia Regina Souza,
Gonçalves Nelcy,
Gomes Flávia CarvalhoAlcantara,
De Freitas Marta Sampaio,
Neto Vivaldo Moura
Publication year - 1998
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/s0736-5748(98)00002-1
Subject(s) - astrocyte , glial fibrillary acidic protein , endocrinology , medicine , hormone , biology , triiodothyronine , hippocampal formation , cerebellum , thyroid , neuroscience , central nervous system , immunohistochemistry
Astrocytes are target to triiodothyronine (T3) hormone action during rat braindevelopment. In this work, we show that astrocytes from distinct developing brain regions aredifferently responsive to thyroid hormone. Distinctly from embryonic or newborn cerebralhemisphere and mesencephalic astrocytes, newborn cerebellar and embryonic hippocampalastrocytes do not change their morphology in response to hormone treatment. We also analysedprotein synthesis and secretion from these T3‐treated astrocytes. The results showed a significantincrease in protein synthesis in astrocytes from older brain regions. Maximum effect, however,was observed in cerebral hemisphere astrocytes from newborn rats. The protein secretion effectwas also more evident in the cerebral hemisphere as well as in cerebellar astrocytes fromnewborn rats. In addition, we examined T3 effects on GFAP/vimentin expression by culturing6‐day old cerebellar astrocytes. In this case T3 seems to induce GFAP expression which might beoccurring as a first step to astrocyte differentiation.