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Developmental expression of the NGF receptor p140 trk in the septohippocampal system of the rat:a quantitative analysis
Author(s) -
Cirulli Francesca,
Shooter Eric M.,
Levine Seymour
Publication year - 1997
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/s0736-5748(97)00020-8
Subject(s) - biology , hippocampus , central nervous system , medicine , endocrinology , gene isoform , nerve growth factor , trk receptor , receptor , cholinergic , messenger rna , hypothalamus , cholinergic neuron , neuroscience , genetics , gene
An RNAse protection assay was used to identify p140 trk mRNA in the developing rat septohippocampal system. In both the septum and hippocampus, levels of p140 trk mRNA were low at birth and increased thereafter. Levels of transcripts were found to be much higher in the septum than in the hippocampus, whereas another brain region, the hypothalamus, showed levels of expression intermediate between these two structures. Only one isoform of the p140 trk receptor was found to be expressed in the rat central nervous system (CNS) during development. This isoform corresponds to the one preferentially expressed in neural tissues in the adult animal. These data show that expression of the high affinity nerve growth factor (NGF) receptor is developmentally regulated during postnatal brain development and suggest that it might mediate NGF effects on developing central cholinergic systems.