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Developmentally regulated serotonin 5‐HT 2B receptors
Author(s) -
Nebigil C.G.,
Etienne N.,
Schaerlinger B.,
Hickel P.,
Launay J.M.,
Maroteaux L.
Publication year - 2001
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/s0736-5748(01)00022-3
Subject(s) - biology , receptor , microbiology and biotechnology , 5 ht receptor , signal transduction , serotonergic , 5 ht2 receptor , serotonin , receptor tyrosine kinase , neuroscience , endocrinology , medicine , genetics
Serotonin (5‐hydroxytryptamine, 5‐HT) binds to numerous cognate receptors to initiate its biological effects. In this review, we have focused on the 5‐HT 2B receptor to address how signaling and expression of this receptor is specifically implicated in embryonic development and adult health and disease. Transduction of the 5‐HT 2B signaling is complex, including phospholipase C and A 2 stimulation, cGMP production and a mitogenic signal that integrates the tyrosine kinase‐signaling pathway. Furthermore, 5‐HT, through the 5‐HT 2B receptors, has the ability to control serotonergic differentiation of committed neuron‐like cells. In addition, 5‐HT 2B receptors are actively involved in the transient action of 5‐HT during embryonic morphogenesis. Our recent data presented the first genetic evidence that 5‐HT via 5‐HT 2B receptors regulates cardiac embryonic development and adult functions and suggested that this receptor subtype may be involved in other physiopathological situations. In particular, 5‐HT‐dependent molecular mechanisms may be involved in embryonic development and postnatal maturation of the enteric nervous system. Also, the involvement of the 5‐HT 2B receptor in the vascular growth often observed in hypertension is likely. These probably result from reactivation of developmentally regulated receptors in pathological situations. Finally, embryonic functions of 5‐HT 2 receptors observed in Drosophila gastrulation suggest evolutionary conserved mechanisms.