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Oxidative damage in Alzheimer's disease: the metabolic dimension
Author(s) -
Perry George,
Nunomura Akihiko,
Hirai Keisuke,
Takeda Atsushi,
Aliev Gjumrakch,
Smith Mark A.
Publication year - 2000
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/s0736-5748(00)00006-x
Subject(s) - lipid peroxidation , oxidative damage , disease , oxidative phosphorylation , neuroscience , nitration , oxidative stress , programmed cell death , nucleic acid , alzheimer's disease , chemistry , biology , biochemistry , medicine , pathology , apoptosis , organic chemistry
Abstract Cell bodies of neurons at risk of death in Alzheimer disease have increased lipid peroxidation, nitration, free carbonyls, and nucleic acid oxidation. These oxidative changes are uniform among neurons and are seen whether or not the neurons display neurofibrillary tangles and, in fact, are acutally reduced in the latter case. In consideration of this localization of damage, in this review, we provide a summary of recent work demonstrating some key abnormalities that may initiate and promote neuronal oxidatave damage.