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Carrageenan‐induced subacromial bursitis caused changes in the rat's rotator cuff
Author(s) -
Tillander Bo,
Franzén Lennart E.,
Nilsson Elise,
Norlin Rolf
Publication year - 2001
Publication title -
journal of orthopaedic research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.041
H-Index - 155
eISSN - 1554-527X
pISSN - 0736-0266
DOI - 10.1016/s0736-0266(00)90022-6
Subject(s) - bursitis , staining , medicine , tendon , carrageenan , metaplasia , saline , rotator cuff , pathology , anatomy , surgery , pharmacology
Abstract This study was designed to investigate the histologic expression of the rat's supra‐ and infraspinatus tendons in carrageenan‐induced subacromial bursitis. Thirty‐two rats received subacromial injections with carrageenan ( n = 28) or saline ( n = 4). The tendons were analysed microscopically after staining with hematoxyline eosin, Van Giesons hematoxyline and immunofluorescent staining of fibronectin and fibrinogen. In the controls (saline × 10) and group A (carrageenan × 5) there were no changes in the tendons. In group B (carrageenan × 10) 3/8 rats showed macrophages between the collagen fibres and an increased staining of fibronectin. In group C (double dosis carrageenan) all rats had signs of fibrocartilaginous metaplasia in the supraspinatus tendon. In eight of these specimens even bony metaplasia was seen. The infraspinatus tendon showed fibrosis but no fibro‐cartilaginous metaplasia. The results showed that iatrogenic bursitis after carrageenan subacromial injections was associated with marked changes of the supraspinatus tendon. © 2001 Orthopaedic Research Society. Published by Elsevier Science Ltd. All rights reserved.