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Mesial temporal lobe epilepsy: A pathological replay of developmental mechanisms?
Author(s) -
Cohen Ivan,
Navarro Vincent,
Duigou Caroline,
Miles Richard
Publication year - 2003
Publication title -
biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 85
eISSN - 1768-322X
pISSN - 0248-4900
DOI - 10.1016/s0248-4900(03)00081-9
Subject(s) - biology , hippocampal sclerosis , neuroscience , epilepsy , pathological , gabaergic , temporal lobe , hippocampal formation , mesial temporal lobe epilepsy , anatomy , pathology , medicine , inhibitory postsynaptic potential
Focal epilepsies of the mesial temporal lobe are often associated with a hippocampal sclerosis. Changes in Cl homeostasis and GABAergic signalling in downstream regions, may contribute to the human pathology. A review of changes in cellular and synaptic function and connectivity after de‐afferentation suggests this epileptic syndrome may involve a pathological replay of developmental mechanisms.