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c‐Mos and cyclin B/cdc2 connections during Xenopus oocyte maturation
Author(s) -
Castro Anna,
Peter Marion,
Lorca Thierry,
Mandart Elisabeth
Publication year - 2001
Publication title -
biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 85
eISSN - 1768-322X
pISSN - 0248-4900
DOI - 10.1016/s0248-4900(01)01128-5
Subject(s) - xenopus , oocyte , biology , maturation promoting factor , cyclin dependent kinase 1 , microbiology and biotechnology , meiosis ii , cyclin b , meiosis , cyclin , cyclin b1 , phosphorylation , oocyte activation , cell cycle , genetics , embryo , cell , gene
Summry— Fully‐grown G2 arrested Xenopus oocytes can be induced to enter and progress into meiotic cell cycle by progesterone stimulation. This process is termed oocyte maturation. An early response to progesterone is the synthesis of the onco‐protein c‐Mos, defined as the candidate initiator of Xenopus oocyte maturation, which triggers the MAPK cascade, MPF activation and promotes CSF activity. Here we review our current knowledge on the synthesis, activation and functions of c‐Mos in connection with MPF activation during maturation. We also discuss our recent results concerning the dispensability of cyclin B degradation in meiosis I‐meiosis II transition and the stabilization of c‐Mos through its direct phosphorylation by cyclin B/cdc2.