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From progesterone to active Cdc2 in Xenopus oocytes: a puzzling signalling pathway
Author(s) -
Karaiskou Anthi,
Dupré Aude,
Haccard Olivier,
Jessus Catherine
Publication year - 2001
Publication title -
biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 85
eISSN - 1768-322X
pISSN - 0248-4900
DOI - 10.1016/s0248-4900(01)01126-1
Subject(s) - xenopus , biology , microbiology and biotechnology , cyclin dependent kinase 1 , protein kinase a , kinase , signal transduction , mitogen activated protein kinase , signalling , prophase , biochemistry , cell cycle , apoptosis , gene , meiosis
Summry— Since almost two decades, it is known that progesterone is responsible of the release of the prophase I arrest of amphibian oocytes and leads to the activation of the universal MPF, through a puzzling transduction pathway. It involves negative regulation of the cAMP‐dependent protein kinase (PKA) and synthesis of new proteins, among them the c‐Mos protooncogene product. The implication of the Mos/mitogenic activated protein kinase (MAP kinase) pathway in Cdc2 activation has been extensively studied and is now at the centre of a controversial debate. In this paper, we discuss the current progress and our recent results on the molecular mechanisms allowing progesterone to activate MPF and propose a model to partly resolve the long‐standing inconsistencies concerning the role of Mos/MAP kinase during this process.