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Integrins: Regulators of embryogenesis
Author(s) -
Darribère Thierry,
Skalski Mylène,
Cousin Hélène,
Gaultier Alban,
Montmory Colette,
Alfandari Dominique
Publication year - 2000
Publication title -
biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 85
eISSN - 1768-322X
pISSN - 0248-4900
DOI - 10.1016/s0248-4900(00)88760-2
Subject(s) - integrin , biology , microbiology and biotechnology , cell adhesion , extracellular matrix , transmembrane protein , cell adhesion molecule , fibronectin , glycoprotein , cytoskeleton , cell , receptor , biochemistry
Summary— Integrins are heterodimeric transmembrane glycoproteins involved in cell‐cell and cell‐extracellular matrix adhesion. They also participate in cytoskeletal rearrangements, co‐regulation of growth factor activities and activation of signal transductions. This review describes experimental approaches that have given new insights into the integrin functions during embryogenesis. Using anti‐functional antibodies, peptide inhibitors of integrin‐ligand interactions and genetic ablation of integrins results, this review will show that integrins are key molecules during early development of both invertebrates and vertebrates.