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Focal adhesions: Structure and dynamics
Author(s) -
Petit Valérie,
Thiery JeanPaul
Publication year - 2000
Publication title -
biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 85
eISSN - 1768-322X
pISSN - 0248-4900
DOI - 10.1016/s0248-4900(00)01101-1
Subject(s) - focal adhesion , extracellular matrix , biology , microbiology and biotechnology , transmembrane protein , extracellular , cytoplasm , actin cytoskeleton , cytoskeleton , cell adhesion , actin , cell migration , ptk2 , morphogenesis , integrin , adhesion , cell , receptor , signal transduction , genetics , chemistry , gene , mitogen activated protein kinase kinase , protein kinase c , organic chemistry
Interactions of cells with the extracellular matrix are essential for the control of tissue remodelling, cell migration, and embryogenesis. At the cell—extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where transmembrane adhesion receptors provide a structural link between the actin cytoskeleton and the extracellular matrix components. Numerous structural and regulatory proteins assemble at the cytoplasmic face of focal adhesions in a Rho‐dependent fashion.