Open AccessEkspresja antygenu Fas i FasL na limfocytach T i B w przerosłych migdałkach gardłowych u dzieci chorych na wysiękowe zapalenie ucha
Author(s) -
Beata Żelazowska-Rutkowska,
Jolanta Wysocka,
Karol Ratomski,
Bożena Skotnicka,
Janusz Żak,
Małgorzata Mrugacz
Publication year - 2008
Publication title -
otolaryngologia polska
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.263
H-Index - 15
eISSN - 2300-8423
pISSN - 0030-6657
DOI - 10.1016/s0030-6657(08)70210-5
Subject(s) - fas ligand , cd19 , medicine , apoptosis , cd8 , antigen , fas receptor , immunology , lymphocyte , adenoid , microbiology and biotechnology , biology , programmed cell death , biochemistry
Apoptosis of lymphocytes can be induced by different factors mainly however the activation of antigen Fas (CD95) and his ligand FasL (CD95L) route. Apoptosis induced by Fas-FasL has large significance in elimination of lymphocytes T in final phase immune response designate AICD (activation induced cell death). Lymphocytes B undergo apoptosis induced by Fas-FasL in germinal center, which has special meaning in elimination of cells about low specificity and weak affinity of receptor BCR ( B-cell antigen receptor).