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Prevalence and genotyping of HPV in cervical cancer among Australian women
Author(s) -
Chen S.,
O'sullivan H.,
Tabrizi S.N.,
Fairley C.K.,
Quinn M.A.,
Garland S.M.
Publication year - 1999
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/s0020-7292(99)00167-8
Subject(s) - medicine , genotyping , cervical cancer , hpv infection , exact test , genotype , oncology , population , cancer , gynecology , biology , genetics , gene , environmental health
Objective: To investigate the association between HPV DNA detection and histological examination of tumor biopsies from women with cervical cancer. Method: A total of 186 women with cervical cancer were screened for HPV infection using MY09/MY11 primer based PCR. The status of HPV infection was correlated with histological and demographic characteristics by Fisher's exact test or Chi square test. Result : The prevalence of HPV infection in this Australian population was 91.9% (171). Among these 53.8% (100) were HPV type 16, 17.2% (32) HPV type 18, and 21.0% (39) other HPV types. Three significant associations were identified: (1) HPV genotype 18 and adenocarcinomas/adenosquamous carcinomas ( P <0.001); (2) HPV DNA negativity and postmenopausal status ( P =0.02); and (3) HPV DNA positivity and lymphocyte infiltration of tumor tissues ( P =0.03). Conclusion : HPV infection is present in the vast majority of cervical cancer patients. However, its presence or genotyping does not seem to have a major influence on the pathogenesis of cervical cancer, such as tumor grade, FIGO staging and metastasis ( P >0.1).