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Plasma lipid concentrations in preeclamptic and normotensive Peruvian women
Author(s) -
WareJauregui S.,
Sanchez S.E.,
Zhang C.,
Laraburre G.,
King I.B.,
Williams M.A.
Publication year - 1999
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/s0020-7292(99)00161-7
Subject(s) - quartile , medicine , triglyceride , eclampsia , endocrinology , body mass index , odds ratio , confounding , cholesterol , dyslipidemia , confidence interval , pregnancy , obesity , biology , genetics
Objectives: Dyslipidemia is thought to be of etiological importance in preeclampsia. We studied the relationship between maternal plasma lipid concentrations and risk of preeclampsia. Methods: A total of 125 preeclampsia cases and 179 normotensive control subjects were included in this case‐control study conducted in Lima, Peru, between August 1997 and January 1998. Post‐diagnosis, antepartum plasma lipid profiles were determined by standard enzymatic methods. Logistic regression procedures were used to calculate odds ratios (OR) adjusted for potential confounders. Results: Mean plasma total cholesterol and triglyceride concentrations were, on average, 6% and 21% higher in preeclamptics than controls, respectively. High‐density lipoprotein (HDL) cholesterol concentrations were, on average, 9% lower in cases than controls. After adjusting for maternal age, pre‐pregnancy body mass index, education, parity and other potential confounders, the risk of preeclampsia increased with successively higher quartiles of plasma triglyceride (adjusted OR: 1.00, 1.62, 2.21, 5.00, with the lowest quartile as referent; P ‐value for trend <0.001). The association between preeclampsia risk and plasma total cholesterol was much less pronounced. In general, there was an inverse association between preeclampsia risk and HDL cholesterol concentration (adjusted OR: 1.00, 0.41, 0.50, 0.38, with the first quartile as the referent group; P ‐value for trend =0.02). Conclusions: These findings suggest that high triglyceride and low HDL cholesterol concentrations are important risk factors for preeclampsia among Peruvian women.