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Uterine and fetal Doppler flow changes after misoprostol and oxytocin therapy for induction of labor in post‐term pregnancies
Author(s) -
Lemancewicz A.,
Urban R.,
Skotnicki M.Z.,
Karpiuk A.,
Urban J.
Publication year - 1999
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/s0020-7292(99)00160-5
Subject(s) - misoprostol , oxytocin , medicine , blood flow , obstetrics , umbilical artery , myometrium , diastole , uterine artery , perfusion , labor induction , uterus , pregnancy , gestation , blood pressure , abortion , biology , genetics
Objectives: To compare the effect of misoprostol vs. oxytocin on blood flow in uteroplacental circulation during labor induction. Methods : Ninety‐one women with indications for induction of labor were assigned to receive either misoprostol 50 μg per vagina every 4 h as needed or intravenous oxytocin by means of a randomization table generated by computer. Doppler velocimetry of umbilical, uterine and arcuate arteries was performed immediately before and 2–3 h after administration of misoprostol or oxytocin. Pulsatility index (PI), resistance index (RI) and systolic/diastolic (S/D) ratios were measured for these arteries. The SAS system was used to perform statistical analysis. Results : There were no significant changes of PI, RI and S/D ratios in umbilical arteries during misoprostol and oxytocin inductions. Vaginal application of misoprostol significantly increased PI, RI and S/D ratios in arcuate arteries and S/D ratio in uterine arteries. Conclusions: Our results indicate that intravaginal misoprostol administration increases uteroplacental resistance but probably does not substantially affect placental perfusion.