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Medical management of non‐viable early first trimester pregnancy
Author(s) -
Autry A.,
Jacobson G.,
Sandhu R.,
Isbill K.
Publication year - 1999
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/s0020-7292(99)00115-0
Subject(s) - misoprostol , medicine , obstetrics , medical abortion , abortion , pregnancy , methotrexate , gestation , gynecology , randomized controlled trial , products of conception , surgery , genetics , biology
Objective: To compare the efficacy of intramuscular methotrexate plus vaginal misoprostol to vaginal misoprostol alone in completing abortion in women with non‐viable early first trimester pregnancy. Method: Twenty‐one women with non‐viable pregnancy up to 49 days gestation were randomized to receive intramuscular methotrexate, followed 2 days later by vaginal misoprostol or misoprostol alone. We also collected patient satisfaction information. Result: Complete abortion occurred in all 12 (100%) women in the combined group and eight of nine (89%, RR=1.13, CI 0.89–1.42) women in the misoprostol only group. Of the women, 75% rated their experience as good and would choose medical management again. Conclusion: Either methotrexate plus misoprostol or misoprostol alone effectively completed abortion in women with non‐viable early pregnancy and represent acceptable medical alternatives to surgery or expectant management.