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Calcium metabolism in pre‐eclampsia
Author(s) -
Ray J.,
Vasishta K.,
Kaur S.,
Majumdar S.,
Sawhney H.
Publication year - 1999
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/s0020-7292(99)00096-x
Subject(s) - calcium , endocrinology , medicine , eclampsia , excretion , calcium metabolism , calcium in biology , urine , preeclampsia , calcium atpase , urinary calcium , atpase , chemistry , biology , pregnancy , biochemistry , enzyme , genetics
Objectives: To study calcium metabolism in pre‐eclampsia and normotensive gravid women. Method: Ten milliliters of heparinized blood samples and 24‐h urine samples were collected from 50 pre‐eclamptic and 50 normotensive primigravidae. Blood samples were studied for calcium uptake, intracellular calcium level and calcium‐dependent adenosine triphosphatase activity of red blood cell ghost. Urinary calcium excretion was estimated from the 24‐h urine samples. These values were compared in the two groups. Results: The mean gestational age at recruitment was similar in both the groups. The mean maternal age was 24.28±2.41 years in pre‐eclamptic and 23.48±4.16 years in normotensive women. In pre‐eclampsia 24‐h urinary calcium excretion (71.20±22.95 mg/day) and calcium‐dependent ATPase activity (10.78±2.40 nmol/P i /mg protein/min) was significantly lower compared to normotensive primigravidae (calcium excretion=189.24±57.06 mg/day; Ca 2+ ‐dependent ATPase=12.64±2.42 nmolPi/mg /protein per min; P <0.001). Intracellular calcium levels and calcium uptake at 10 min by red blood cells were significantly higher in pre‐eclampsia ( P <0.05). Calcium uptake by red blood cells at 20 and 30 min was similar in both groups. Conclusion: Pre‐eclampsia is associated with increased levels of intracellular calcium, decreased calcium‐dependent ATPase activity of erythrocytes and hypocalciuria.