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Prognostic factors relating to survival in uterine endometrioid carcinoma
Author(s) -
Hirai M.,
Hirono M.,
Oosaki T.,
Hayashi Y.,
Yoshihara T.,
Matsuzaki O.
Publication year - 1999
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/s0020-7292(99)00067-3
Subject(s) - medicine , carcinoma , oncology , gynecology
Objective : Epidemiologic and clinicohistopathologic prognostic factors of uterine endometrioid carcinomas were analyzed. The association of estrogen related factors, focused on adenomyosis in the prognosis of endometrioid carcinomas was also examined. Methods : Risk factors of surgically treated 286 patients with endometrioid carcinoma (Stage I–III) were statistically analyzed. Results : Overall a recurrence‐free 5‐year survival rate was 81% (Stage I, 94%, Stage II, 71% and Stage III, 40%). Significant prognostic factors were lymph node metastases ( P =0.0035) and serosal/parametrial invasion ( P =0.014) by multivariate analysis. Endometrioid carcinomas with co‐existing adenomyosis tend to be associated with endometrial hyperplasia ( P =0.04, Fisher's exact test), diagnosed in less invasive status (myometrial invasion, P =0.004 and serosal/parametrial invasion, P =0.006) and therefore have a favorable prognosis ( P =0.01, log rank test). Conclusions : A favorable prognosis of endometrioid carcinomas with co‐existing estrogen related factors (adenomyosis and endometrial hyperplasia) was suggested.